Sam Hayutin was a Jewish Denverite, who married Bess Gorden. He went into business with his brother-in-law, Charles Yale. The two founded Yale Drug, although Sam was not a pharmacist. The two owned and operated the pharmacy from 1949 until the 1960s. Both Sam and Charles' wives and children worked in the store. The two opened an extension, Yale Pharmacy, during the late 1950s. This store was sold to Sam's son, Arnold, in the 1960s. Shortly after, Charles bought Sam's interest in Yale Drug.